Risk of fetal diabetes: Diabetes due to modern lifestyle (Diabetes) The increased risk of acetaminophen and its side effects cause concern. According to a report in the Daily Jagran, a new study has now found that mothers who control their blood sugar levels by controlling their diabetes and insulin can cause permanent damage to the fetus. The results of the study were published in the journal Science Advances.
Let us tell you that about 60 million women worldwide with diabetes become mothers every year. Of these, neural tube defects are the cause of diabetes in the mother of millions of fetuses. For this reason, the fetal brain and spinal cord do not develop properly. For this reason, the risk of miscarriage or severe disability in children also increases.
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Researchers at the University of Maryland School of Medicine (UMSOM) have used the mouse model to find the cause of this birth defect. Study Has done. According to which, premature aging of neural tissue occurs, due to which enough cells are shut down to form neural tubes.
Pexin Young, a professor at the UMSOM Center for Birth Defects Research, who led the study, said: “Diabetes is generally considered to be a disease of the elderly. We also now know that high blood glucose induces or accelerates premature aging of the fetus. “
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Professor Pixin Young added that although it has been said for decades that maternal diabetes leads to premature fetal age, which causes babies to suffer from congenital malformations. But we’ve recently got the tools and technology to test this thing.
Problems can be prevented if there is information
The fact that mothers are aware of the whole process of fetal malformation due to diabetes will pave the way for them to find ways to prevent it. During the study, the researchers used a cancer drug to slow down the process of tissue aging, which led to the full development of neural tubes in diabetic rat embryos. Based on this discovery, proper therapy can be developed to prevent miscarriage or many types of birth defects in children.
Fetal error detection
Researchers have previously found signs of premature aging in eight-day-old rats with diabetes. These signs were not found in children who did not have diabetes. It has also been found that premature aging markers in cells emit large amounts of chemical nited, which destroys nearby cells.
At a later stage of the study, children born to diabetic mothers were given a cancer drug, rapamycin. This drug is used to block the secretion or signal of toxic chemicals from premature aging cells. It was then found that the neural tube was fully developed during the administration of rapamycin. It was like a baby born to a healthy mother.
It was found that the aging cells started behaving normally with this drug. But unfortunately, many other cells were also attacked by rapamycin. Therefore, this drug may not be suitable for preventing neural tube deformity. Some other treatment options need to be found.
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